Lymphatic filariasis: possible pathophysiological nexus with oxidative stress
Identifieur interne : 007A74 ( Main/Exploration ); précédent : 007A73; suivant : 007A75Lymphatic filariasis: possible pathophysiological nexus with oxidative stress
Auteurs : B. K. Pal [Inde] ; S. Kulkarni [Inde] ; Y. Bhandari [Inde] ; Balaji B. Ganesh [Inde] ; K. Goswami [Inde] ; M. V. R. Reddy [Inde]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2006-07.
Descripteurs français
- KwdFr :
- Adulte, Antigènes d'helminthe (sang), Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (métabolisme), Filariose lymphatique (traitement médicamenteux), Humains, Inde (épidémiologie), Maladie chronique, Malonaldéhyde (sang), Mâle, Santé en zone rurale, Stress oxydatif (physiologie), Superoxide dismutase (sang).
- MESH :
- immunologie : Filariose lymphatique.
- métabolisme : Filariose lymphatique.
- physiologie : Stress oxydatif.
- sang : Antigènes d'helminthe, Malonaldéhyde, Superoxide dismutase.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- épidémiologie : Inde.
- Adulte, Femelle, Humains, Maladie chronique, Mâle, Santé en zone rurale.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adult, Antigens, Helminth (blood), Chronic Disease, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (metabolism), Female, Filaricides (therapeutic use), Humans, India (epidemiology), Inflammation, Lymphatic filariasis, Male, Malondialdehyde (blood), Oxidative Stress (physiology), Oxidative stress, Rural Health, Superoxide Dismutase (blood).
- MESH :
- chemical , blood : Antigens, Helminth, Malondialdehyde, Superoxide Dismutase.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- geographic , epidemiology : India.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial.
- metabolism : Elephantiasis, Filarial.
- physiology : Oxidative Stress.
- Adult, Chronic Disease, Female, Humans, Male, Rural Health.
Abstract
Wuchereria bancrofti-mediated lymphatic filariasis is widely prevalent. Diversity in immune response presumably may lead to myriad clinical presentations, such as overt chronic filariasis, occult filariasis with atypical systemic manifestation and asymptomatic microfilariae carrier state. Anticipated oxidative stress during inflammatory response to infective conditions might complicate the immune response and thus might alter the disease outcome. The present study was carried out to assess the status of oxidative stress in different clinical presentations of bancroftian filariasis. Twenty-five microfilariae carriers and 30 cases each of chronic filariasis and occult filariasis were compared to 30 endemic normal individuals. Serum malondialdehyde level and superoxide dismutase enzyme activity were measured by spectrophotometric methods and levels of filarial antigen were measured by ELISA. In the filarial cases, the levels of these parameters were assayed again after treatment with diethylcarbamazine citrate (DEC). Results showed significant (P < 0.05) association of oxidative stress with chronic and occult filariasis but not with microfilarial carriers. DEC therapy in both clinical cases and carriers resulted in a significant reduction of oxidative stress associated with decreased antigen level (P < 0.01). These findings suggest the possible involvement of oxidative stress in filarial disease pathology.
Url:
DOI: 10.1016/j.trstmh.2005.10.017
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000291
- to stream Istex, to step Curation: 000291
- to stream Istex, to step Checkpoint: 001558
- to stream PubMed, to step Corpus: 003A47
- to stream PubMed, to step Curation: 003A47
- to stream PubMed, to step Checkpoint: 003A47
- to stream Ncbi, to step Merge: 002166
- to stream Ncbi, to step Curation: 002166
- to stream Ncbi, to step Checkpoint: 002166
- to stream Main, to step Merge: 007C67
- to stream Main, to step Curation: 007A74
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Lymphatic filariasis: possible pathophysiological nexus with oxidative stress</title><author><name sortKey="Pal, B K" sort="Pal, B K" uniqKey="Pal B" first="B. K." last="Pal">B. K. Pal</name></author><author><name sortKey="Kulkarni, S" sort="Kulkarni, S" uniqKey="Kulkarni S" first="S." last="Kulkarni">S. Kulkarni</name></author><author><name sortKey="Bhandari, Y" sort="Bhandari, Y" uniqKey="Bhandari Y" first="Y." last="Bhandari">Y. Bhandari</name></author><author><name sortKey="Ganesh, Balaji B" sort="Ganesh, Balaji B" uniqKey="Ganesh B" first="Balaji B." last="Ganesh">Balaji B. Ganesh</name></author><author><name sortKey="Goswami, K" sort="Goswami, K" uniqKey="Goswami K" first="K." last="Goswami">K. Goswami</name></author><author><name sortKey="Reddy, M V R" sort="Reddy, M V R" uniqKey="Reddy M" first="M. V. R." last="Reddy">M. V. R. Reddy</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:06357623C6EB4B25EBE429D366D6B360440E869A</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1016/j.trstmh.2005.10.017</idno><idno type="url">https://api.istex.fr/document/06357623C6EB4B25EBE429D366D6B360440E869A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000291</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000291</idno><idno type="wicri:Area/Istex/Curation">000291</idno><idno type="wicri:Area/Istex/Checkpoint">001558</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001558</idno><idno type="wicri:doubleKey">0035-9203:2006:Pal B:lymphatic:filariasis:possible</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16554077</idno><idno type="wicri:Area/PubMed/Corpus">003A47</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A47</idno><idno type="wicri:Area/PubMed/Curation">003A47</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003A47</idno><idno type="wicri:Area/PubMed/Checkpoint">003A47</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003A47</idno><idno type="wicri:Area/Ncbi/Merge">002166</idno><idno type="wicri:Area/Ncbi/Curation">002166</idno><idno type="wicri:Area/Ncbi/Checkpoint">002166</idno><idno type="wicri:doubleKey">0035-9203:2006:Pal B:lymphatic:filariasis:possible</idno><idno type="wicri:Area/Main/Merge">007C67</idno><idno type="wicri:Area/Main/Curation">007A74</idno><idno type="wicri:Area/Main/Exploration">007A74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Lymphatic filariasis: possible pathophysiological nexus with oxidative stress</title><author><name sortKey="Pal, B K" sort="Pal, B K" uniqKey="Pal B" first="B. K." last="Pal">B. K. Pal</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation></author><author><name sortKey="Kulkarni, S" sort="Kulkarni, S" uniqKey="Kulkarni S" first="S." last="Kulkarni">S. Kulkarni</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation></author><author><name sortKey="Bhandari, Y" sort="Bhandari, Y" uniqKey="Bhandari Y" first="Y." last="Bhandari">Y. Bhandari</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation></author><author><name sortKey="Ganesh, Balaji B" sort="Ganesh, Balaji B" uniqKey="Ganesh B" first="Balaji B." last="Ganesh">Balaji B. Ganesh</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation></author><author><name sortKey="Goswami, K" sort="Goswami, K" uniqKey="Goswami K" first="K." last="Goswami">K. Goswami</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation></author><author><name sortKey="Reddy, M V R" sort="Reddy, M V R" uniqKey="Reddy M" first="M. V. R." last="Reddy">M. V. R. Reddy</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of medical Sciences, Sevagram, Maharashtra 442102</wicri:regionArea><wicri:noRegion>Maharashtra 442102</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Inde</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="ISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2006-07">2006-07</date><biblScope unit="volume">100</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="650">650</biblScope><biblScope unit="page" to="655">655</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Helminth (blood)</term><term>Chronic Disease</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (metabolism)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>India (epidemiology)</term><term>Inflammation</term><term>Lymphatic filariasis</term><term>Male</term><term>Malondialdehyde (blood)</term><term>Oxidative Stress (physiology)</term><term>Oxidative stress</term><term>Rural Health</term><term>Superoxide Dismutase (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Antigènes d'helminthe (sang)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (métabolisme)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Inde (épidémiologie)</term><term>Maladie chronique</term><term>Malonaldéhyde (sang)</term><term>Mâle</term><term>Santé en zone rurale</term><term>Stress oxydatif (physiologie)</term><term>Superoxide dismutase (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term><term>Malondialdehyde</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Malonaldéhyde</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Chronic Disease</term><term>Female</term><term>Humans</term><term>Male</term><term>Rural Health</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Maladie chronique</term><term>Mâle</term><term>Santé en zone rurale</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Wuchereria bancrofti-mediated lymphatic filariasis is widely prevalent. Diversity in immune response presumably may lead to myriad clinical presentations, such as overt chronic filariasis, occult filariasis with atypical systemic manifestation and asymptomatic microfilariae carrier state. Anticipated oxidative stress during inflammatory response to infective conditions might complicate the immune response and thus might alter the disease outcome. The present study was carried out to assess the status of oxidative stress in different clinical presentations of bancroftian filariasis. Twenty-five microfilariae carriers and 30 cases each of chronic filariasis and occult filariasis were compared to 30 endemic normal individuals. Serum malondialdehyde level and superoxide dismutase enzyme activity were measured by spectrophotometric methods and levels of filarial antigen were measured by ELISA. In the filarial cases, the levels of these parameters were assayed again after treatment with diethylcarbamazine citrate (DEC). Results showed significant (P < 0.05) association of oxidative stress with chronic and occult filariasis but not with microfilarial carriers. DEC therapy in both clinical cases and carriers resulted in a significant reduction of oxidative stress associated with decreased antigen level (P < 0.01). These findings suggest the possible involvement of oxidative stress in filarial disease pathology.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Pal, B K" sort="Pal, B K" uniqKey="Pal B" first="B. K." last="Pal">B. K. Pal</name></noRegion><name sortKey="Bhandari, Y" sort="Bhandari, Y" uniqKey="Bhandari Y" first="Y." last="Bhandari">Y. Bhandari</name><name sortKey="Bhandari, Y" sort="Bhandari, Y" uniqKey="Bhandari Y" first="Y." last="Bhandari">Y. Bhandari</name><name sortKey="Ganesh, Balaji B" sort="Ganesh, Balaji B" uniqKey="Ganesh B" first="Balaji B." last="Ganesh">Balaji B. Ganesh</name><name sortKey="Ganesh, Balaji B" sort="Ganesh, Balaji B" uniqKey="Ganesh B" first="Balaji B." last="Ganesh">Balaji B. Ganesh</name><name sortKey="Goswami, K" sort="Goswami, K" uniqKey="Goswami K" first="K." last="Goswami">K. Goswami</name><name sortKey="Kulkarni, S" sort="Kulkarni, S" uniqKey="Kulkarni S" first="S." last="Kulkarni">S. Kulkarni</name><name sortKey="Reddy, M V R" sort="Reddy, M V R" uniqKey="Reddy M" first="M. V. R." last="Reddy">M. V. R. Reddy</name><name sortKey="Reddy, M V R" sort="Reddy, M V R" uniqKey="Reddy M" first="M. V. R." last="Reddy">M. V. R. Reddy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007A74 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007A74 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:06357623C6EB4B25EBE429D366D6B360440E869A
|texte= Lymphatic filariasis: possible pathophysiological nexus with oxidative stress
}}
| This area was generated with Dilib version V0.6.31. |  |